Estradot TTS is a type of hormone replacement therapy (HRT) that contains the active ingredient estradiol, a form of estrogen. It is designed as a transdermal therapeutic system (TTS), meaning it is administered through the skin via a patch. Estradot patches are used primarily by women to relieve symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness. By delivering a steady amount of estradiol directly into the bloodstream, Estradot helps to replenish decreasing estrogen levels in menopausal women, thereby alleviating these uncomfortable symptoms. It may also be prescribed for other conditions as determined by a healthcare provider. The patches are typically applied to a clean, dry area of the lower abdomen or buttocks and are changed according to the prescribed schedule to ensure consistent hormone levels.