Evorel Sequi is a hormone replacement therapy (HRT) medication primarily used to alleviate symptoms associated with menopause in women, such as hot flashes, night sweats, mood swings, and vaginal dryness. It is a sequenced regimen that contains two types of patches: one that delivers estradiol (an estrogen) and another that delivers both estradiol and norethisterone acetate (a progestogen). This combination of hormones helps to mimic the natural menstrual cycle more closely than continuous-combined HRT, making it suitable for women who have not had a hysterectomy and are experiencing menopausal symptoms. The estradiol-only patches are used for the first part of the cycle, followed by the combined estradiol and norethisterone patches, to provide both estrogen replacement and endometrial protection. Evorel Sequi is designed to be applied directly to the skin, offering an alternative to oral HRT, and is appreciated for its convenience and the steady absorption of hormones it provides.