IXIARO is a vaccine used to prevent Japanese encephalitis, a serious and potentially fatal disease caused by the Japanese encephalitis virus. This virus is transmitted to humans through the bite of an infected mosquito, primarily in rural and agricultural areas of Asia and the Western Pacific. The IXIARO vaccine works by stimulating the body's immune system to produce antibodies against the virus, offering protection to those who are vaccinated. It is recommended for travelers to endemic areas, laboratory personnel who may be exposed to the virus, and individuals living in regions where the disease is prevalent. The vaccine is administered in a series of doses, and its safety and efficacy have been established in clinical trials. As with any vaccine, there may be side effects, but IXIARO is generally well-tolerated and considered an important preventive measure against Japanese encephalitis.