Ketoconazole HRA is a pharmaceutical formulation of ketoconazole, a potent antifungal medication primarily used to treat various fungal infections. Unlike the topical version commonly applied to skin infections, Ketoconazole HRA is designed for systemic use, meaning it is taken orally and works from within the body to combat fungal pathogens. It operates by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting cell membrane integrity and leading to the death of the fungal cells. Ketoconazole HRA is often prescribed for conditions that are resistant to other treatments, making it a valuable option in the arsenal against severe or recalcitrant fungal infections. However, due to its potential for causing liver damage and interacting with a wide array of other medications, its use is typically reserved for cases where the benefits outweigh the risks, and it is administered under strict medical supervision.