KOMBOGLYZE is a prescription medication used in the management of type 2 diabetes mellitus in adults. It is a combination of two active ingredients, saxagliptin and metformin hydrochloride, which work together to improve blood sugar control. Saxagliptin belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which help increase the levels of insulin produced by the body after meals and decrease the amount of sugar made by the body. Metformin, on the other hand, works by decreasing glucose production in the liver and improving insulin sensitivity, thus helping the body to utilize insulin more effectively. KOMBOGLYZE is typically prescribed when diet and exercise alone have not been enough to control blood sugar levels, and it may be used alone or with other diabetes medications.