PENNSAID (diclofenac sodium topical solution) is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of pain associated with osteoarthritis, particularly in the knees. It is applied directly to the skin over the affected area, allowing the medication to be absorbed through the skin to provide localized pain relief. PENNSAID works by inhibiting the enzymes responsible for inflammation and pain signaling in the body, offering patients a targeted approach to managing their osteoarthritis symptoms. As with any NSAID, it is important for users to follow the prescribed dosage and be aware of potential side effects, which can include skin irritation at the application site, among others. PENNSAID offers an alternative for those who may prefer or require topical pain management solutions.