PIFELTRO (doravirine) is a prescription medication used in the treatment of Human Immunodeficiency Virus-1 (HIV-1) infection in adults. It belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs), which work by blocking the reverse transcriptase enzyme. This enzyme is crucial for the replication of the HIV virus, and its inhibition helps to decrease the amount of virus in the body. PIFELTRO is often used in combination with other antiretroviral medications as part of an antiretroviral therapy regimen. It is known for its once-daily oral administration, making it a convenient option for many patients. However, it is important to note that while PIFELTRO can help manage HIV infection, it does not cure HIV/AIDS and does not prevent the transmission of the virus to others.