Relifex is a brand name for the nonsteroidal anti-inflammatory drug (NSAID) nabumetone, which is used to relieve symptoms associated with osteoarthritis and rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain. Unlike some other NSAIDs, Relifex is designed to be gentler on the stomach, as it is a prodrug that is converted into its active form only after absorption into the bloodstream. This medication is typically taken orally in tablet form and is meant for long-term treatment of arthritis symptoms. As with any NSAID, it is important to use Relifex under the guidance of a healthcare provider, as it can have side effects and interact with other medications.