Rukobia (fostemsavir) is a prescription medication used in the treatment of HIV/AIDS. It is specifically designed for adults who have tried multiple HIV medications in the past but whose HIV infection has become resistant to their current treatment regimen. Rukobia works by a mechanism different from other antiretroviral drugs; it is a gp120 attachment inhibitor. This means it blocks the virus's ability to bind to and enter human immune cells, thereby preventing the virus from replicating. Rukobia is typically used in combination with other HIV medications to provide a comprehensive approach to managing the virus. Its approval offers a new hope for patients with limited treatment options due to resistance to other drugs.