Vagifem is a prescription medication primarily used to treat symptoms of vaginal atrophy associated with menopause. It contains the hormone estradiol, which is a form of estrogen. Vagifem works by delivering a low dose of estradiol directly to the vaginal tissue, helping to replenish the diminished estrogen levels that are common during menopause. This can lead to an improvement in symptoms such as vaginal dryness, itching, and irritation. Vagifem is typically administered in the form of a vaginal tablet. As with any hormone replacement therapy, it's important for patients to discuss the benefits and risks of using Vagifem with their healthcare provider, especially considering factors like personal and family medical history.