Zestoretic 20 is a prescription medication that combines two active ingredients: 20 mg of lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, and 12.5 mg of hydrochlorothiazide, a thiazide diuretic. This combination is used primarily to treat high blood pressure (hypertension), helping to prevent strokes, heart attacks, and kidney problems. Lisinopril works by relaxing blood vessels, allowing blood to flow more easily, while hydrochlorothiazide helps rid the body of excess salt and water, further lowering blood pressure. Zestoretic 20 is often prescribed when a single medication is not effective in controlling blood pressure, offering a dual approach to managing hypertension. Patients are advised to take this medication exactly as prescribed by their healthcare provider and to discuss any potential side effects or interactions with other medications.