ZYCLARA (imiquimod) is a topical cream used in the treatment of certain skin conditions, including actinic keratosis (a condition caused by too much sun exposure) on the face or scalp, and external genital and perianal warts caused by the human papillomavirus (HPV). It belongs to a class of medications known as immune response modifiers. ZYCLARA works by stimulating the body's natural defense mechanisms to fight the virus that causes warts and to repair the sun-damaged skin, thereby improving the appearance and texture of the affected areas. It is available by prescription and is applied directly to the skin in a regimen typically involving several weeks of treatment, depending on the condition being treated and the response of the patient to the medication.